Structural semantic evolutionary distance (SSED) unifies the selection of cancer driver genes across macroevolution and tumorigenesis.
Hongchen Ji, Q Y Zhang, Jianwei Wu, Fei Tian, Xiangxu Wang, Xiao Chai, Jiawei Chang, Mengdi Zheng, X. M. Li, Hong-Mei Zhang
This paper introduces SSED, a metric using ESM-3 to quantify evolutionary divergence, showing cancer driver genes are structurally constrained and that oncogenic mutations follow similar principles, predicting immune response.
bioRxiv · Dec 19, 2025 · PreprintGenetics