Author

Felicia Hernandez

Ambry Genetics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:variant effect prediction· 3 Assay:DNA methylation· 2 Assay:whole-exome sequencing· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ashley P.L. MarshiD· 2 shared Jacob Otto KitzmaniD· 2 shared Adam C. Chamberlin· 1 shared Alyssa Bashir· 1 shared Andrew J. WatersiD· 1 shared Anthony J. ScottiD· 1 shared Atina G. CotéiD· 1 shared Cathy SmithiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenomics

Ashley P.L. MarshORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Saturation mapping of MUTYH variant effects using DNA repair reporters

Shelby L. Hemker, Ashley P.L. Marsh, Felicia Hernandez, Elena Glick, Grace Clark, Alyssa Bashir, Krystal Jiang, Jacob Otto Kitzman

The paper maps the functional effects of MUTYH variants using deep mutational scanning and DNA repair reporters, resolving variants of uncertain significance and identifying risk-associated mutations.

The American Journal of Human Genetics · Jul 29, 2025Peer-reviewedGenomics

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor

Daniel Zimmerman, Atina G. Coté, Warren van Loggerenberg, Marinella Gebbia, Nishka Kishore, Jochen Weile, Roujia Li, Chloe Reno, Ashley P.L. Marsh, Felicia Hernandez, Preksha Shahagadkar, Lauren Grove, Samuel R. Meier, Hsin‐Jung Wu, Silvia Fenoglio, , Frederick P. Roth

This study functionally tests STK11 missense variants in mammalian cells, identifying pathogenic variants and providing insights for clinical interpretation.

bioRxiv · Jul 14, 2025 · PreprintCancer Biology

Saturation-scale functional evidence supports clinical variant interpretation in Lynch Syndrome

Anthony J. Scott, Felicia Hernandez, Adam C. Chamberlin, Cathy Smith, Rachid Karam, Jacob Otto Kitzman

This study uses high-throughput functional assays to reclassify variants of uncertain significance in Lynch Syndrome, improving variant interpretation and clinical outcomes.

Genome biology · Dec 22, 2022Peer-reviewedGenetic & Genomic Medicine