M4 drug discovery: human drug predictions from integrated preclinical insights exemplified with a GLP1-R agonist
Oscar Silfvergren, Sophie Rigal, Katharina M. S. Schimek, Christian Simonsson, Kajsa P. Kanebratt, Felix Forschler, Burçak Yesildag, Uwe Marx, Liisa K. Vilén, Peter Gennemark, Gunnar Cedersund
The paper introduces M4 drug discovery, a method that integrates multi-level, multi-timescale, and multi-species data with mechanistic knowledge to predict clinical outcomes of drugs like GLP-1RAs from preclinical data.
European Journal of Pharmaceutical Sciences · Aug 30, 2026Peer-reviewedSystems Biology