Burçak Yesildag

The paper introduces M4 drug discovery, a method that integrates multi-level, multi-timescale, and multi-species data with mechanistic knowledge to predict clinical outcomes of drugs like GLP-1RAs from preclinical data.

The paper identifies ISG15 as a key factor in viral resistance in pancreatic alpha cells, showing its protective role against coxsackievirus B1 in human islet cells.

This paper integrates GLP-1RA exenatide studies across heterogeneous cell systems to address variability, providing a unified conclusion and predicting inter-study variabilities.

This paper shows that long-term cytokine exposure impairs alpha-cell glucagon secretion in human islet microtissues, which is partially restored by dual incretin receptor agonists.