CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma
Karim H Saba, Valeria Difilippo, Emelie Styring, Jenny Nilsson, Linda Magnusson, Hilda van den Bos, Diana C. J. Spierings, Floris Foijer, Michaela Nathrath, Felix Haglund de Flon, Daniel Baumhoer, Karolin H Nord
This study identifies four subgroups of osteosarcomas based on genomic and transcriptomic analysis, revealing distinct mechanisms of CDK4 amplification in relation to MDM2 or TP53 alterations.
bioRxiv · Mar 13, 2024 · PreprintCancer Biology