Multispecies translational evaluation of an NMDA receptor modulator reveals analgesic, autonomic-stabilizing, and stress mitigating effects without evidence of abuse liability
Joanne L. Tuohy, Toshitsugu Ishihara, Sudarshana Govindasamy, Ramu Anandakrishnan, Jennifer L. Davis, Fiona E. Harrison, Yuying Huang, Shao-Rui Chen, huilin Pan, Blaise Mathias Costa
This study evaluates CNS4, an NMDA receptor modulator, across mice, rats, and dogs, showing analgesic, autonomic-stabilizing, and stress-reducing effects without abuse liability.
bioRxiv · Sep 18, 2026 · PreprintPharmacology & Toxicology