Human metabolites modulate antifungal efficacy and reveal creatinine-mediated antagonism of flucytosine
Johannes Hartl, Andrea D. Lehmann, Fiona Wahl, Markus Ralser
The paper identifies human metabolites, particularly creatinine, that reduce the efficacy of the antifungal drug flucytosine by interfering with its uptake.
bioRxiv · Jun 16, 2026 · PreprintBiochemistry