Author

Johannes Hartl

Berlin Institute of Health at Charité - Universitätsmedizin BerlinORCID 0000-0001-8470-5355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Biochemistry· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Assay:metabolomics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Markus RalseriD· 5 shared Michael MüllederiD· 3 shared Andrea D. LehmanniD· 2 shared Oliver LemkeiD· 2 shared Simran Kaur AulakhiD· 2 shared Benjamin Murray HeineikeiD· 1 shared Christoph B. MessneriD· 1 shared Christopher M. JakobsoniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersSystems Biology

Markus RalserORCID

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5 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 16, 2026

Human metabolites modulate antifungal efficacy and reveal creatinine-mediated antagonism of flucytosine

Johannes Hartl, Andrea D. Lehmann, Fiona Wahl, Markus Ralser

The paper identifies human metabolites, particularly creatinine, that reduce the efficacy of the antifungal drug flucytosine by interfering with its uptake.

DOI 10.64898/2026.06.12.731662

humanmetabolomics

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MicrobiologyJournal of Medical MicrobiologyPeer-reviewedJul 28, 2025

Drugs Commonly Used in Fungal Infection Risk Conditions Promote Drug Tolerance or Resistance in Candida albicans

Mariella Obermeier, M. Alejandra Esparza-Mora, Olivia Heese…·Markus Ralser

This study identifies 34 drugs that affect antifungal efficacy in Candida albicans, with some promoting resistance when combined with fluconazole.

4 citations

C. elegansexperimental assay

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Systems BiologyCell SystemsPeer-reviewedJun 13, 2025

The Molecular Landscape of Cellular Metal Ion Biology

Simran Kaur Aulakh, Oliver Lemke, Łukasz Szyrwiel…·Markus Ralser

The paper quantifies yeast cell responses to varying metal ions, revealing widespread proteomic and genetic impacts and common metal responsiveness properties.

19 citationstop 3%

yeastproteomics

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Systems BiologybioRxivPreprintOct 18, 2024

A genome-to-proteome atlas charts natural variants controlling proteome diversity and forecasts their fitness effects

Christopher M. Jakobson, Johannes Hartl, Pauline Trébulle…·Markus Ralser

The paper links genome to proteome in yeast progeny to identify variants controlling proteome diversity and predict their fitness effects under stress.

3 citations

yeastproteomics

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Molecular BiologyPLoS BiologyPeer-reviewedDec 1, 2022

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

Jason Yu, Benjamin Murray Heineike, Johannes Hartl…·Markus Ralser

The paper shows yeast cells can cooperatively compensate for methionine auxotrophy by using a new homocysteine synthase, HSU1, to re-assimilate hydrogen sulfide.

10 citations

yeastexperimental assay

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