The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification
Sally H. Cross, Lisa McKie, Toby W. Hurd, Sam Riley, Jimi C. Wills, Alun R. Barnard, Fiona Young, Robert Edward MacLaren, Ian J. Jackson
This paper identifies TMEM98 as a regulator of eye size by inhibiting MYRF self-cleavage, leading to abnormal nuclear localization and activation of MYRF in the absence of TMEM98.
PLoS Genetics · Apr 1, 2020Peer-reviewedGenetics