Sally H. Cross

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.

This paper identifies TMEM98 as a regulator of eye size by inhibiting MYRF self-cleavage, leading to abnormal nuclear localization and activation of MYRF in the absence of TMEM98.

The paper identifies TMEM98 mutations in mice that cause retinal defects similar to human nanophthalmos, showing localized photoreceptor laminar disruption rather than small eyes.