Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head Injury
Rachel Furhang, Riley Morrone, Elena Nikulina, Mahdavi Jere, Ashmeet Kaur, Fizza Nayab, Takashi Saito, Takaomi C. Saido, Peter John Bergold
This study shows that expressing 3R tau isoforms in mice alters the disease course of traumatic brain injury, leading to different white matter damage and behavioral outcomes at subacute and chronic stages.
bioRxiv · Jul 13, 2026 · PreprintNeuroscience