Elena Nikulina

Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head Injury

This study shows that expressing 3R tau isoforms in mice alters the disease course of traumatic brain injury, leading to different white matter damage and behavioral outcomes at subacute and chronic stages.

Analysis of markerless limb tracking reveals chronic and progressive motor deficits after a single closed head injury in mice

Increased protein kinase Mζ expression by Minocycline and N-acetylcysteine restoreslate-phase long-term potentiation and spatial learning after closed head injury in mice

MN12 treatment increases PKMζ expression, restoring LTP and spatial learning in mice with closed head injury.

A single closed head injury in mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes

This study shows that a single closed head injury in mice causes chronic white matter atrophy and increased phospho-tau in oligodendrocytes, differing from chronic traumatic encephalopathy from repeated injuries.

Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

Delayed dosing of minocycline plus N-acetylcysteine reduces neurodegeneration in distal brain regions and restores spatial memory after experimental traumatic brain injury