Author

Floor Dolsma

Delft University of Technology

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Evolutionary Biology· 1

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Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

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Enzo KingmaiD· 1 shared Leila Iñigo de la CruziD· 1 shared Liedewij LaaniD· 1 shared

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Enzo KingmaORCID

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1 paper

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Evolutionary BiologyPLoS ONEPeer-reviewedFeb 6, 2025

Saturated Transposon Analysis in Yeast as a One-step Method to Quantify the Fitness Effects of Gene Disruptions on a Genome-Wide Scale

Enzo Kingma, Floor Dolsma, Leila Iñigo de la Cruz, Liedewij Laan

The paper introduces a method to quantify gene disruption fitness effects using TIS data in yeast, showing that average read counts per insertion site provide a robust fitness metric.

5 citations

yeastwhole-genome sequencing

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