Florentia M. Smith

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

This study shows Grb10 regulates fetal growth independently of Igf1r and Insr, with some organ-specific interactions, particularly in the liver.

Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism

This study generates Grb7 KO mice and shows Grb7 and Grb14 have minimal impact on fetal growth but Grb7 may promote kidney growth and subtly affects glucose metabolism in adults.