Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects
Maja Šolman, Sasja Blokzijl-Franke, Florian Piques, Chuan Yan, Qiqi Yang, Marion Strullu, Sarah M. Kamel, Pakize Ak, Jeroen Bakkers, David M. Langenau, Hélène Cavé, Jeroen den Hertog
This study identifies an inflammatory response in HSPCs with SHP2 mutations that drives MPN and suggests anti-inflammatory agents as potential therapies for JMML.
eLife · Apr 20, 2022Peer-reviewedDevelopmental Biology