Jeroen den Hertog

This study shows K-Ras4B sustains ciliation during muscle cell differentiation by localizing to the primary cilium, affecting asymmetric cell divisions and differentiation outcomes.

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

This study shows that Shp2 is essential for lymphatic endothelial cell differentiation in zebrafish embryos, without affecting venous angiogenesis.

The paper identifies geraniol-induced ectopic tail formation in zebrafish embryos and shows that Kupffers vesicle derived cells are essential for normal tail morphogenesis.

This study shows that loss of Shp1 in zebrafish leads to myeloid cell dysfunction, inflammation, and larval lethality.

This study identifies an inflammatory response in HSPCs with SHP2 mutations that drives MPN and suggests anti-inflammatory agents as potential therapies for JMML.

The paper investigates how PI3K signaling affects survival and stemness of zebrafish HSPCs during EHT, finding that both loss of Pten and PI3K inhibition induce apoptosis, while surviving cells show reduced stemness.