Jeroen Bakkers

This study identifies a zebrafish-specific gene regulatory network where Isl1 restricts Nkx2-5 to maintain pacemaker identity, distinct from mammalian mechanisms.

This study shows that fasting improves PLN R14del cardiomyopathy by restoring lysosomal function and reducing SR-derived vesicle accumulation.

This study identifies an inflammatory response in HSPCs with SHP2 mutations that drives MPN and suggests anti-inflammatory agents as potential therapies for JMML.

This paper introduces EpiDamID, a method to profile histone modifications and transcriptomes at single-cell resolution, and demonstrates its application in mouse and zebrafish systems.

This study identifies Prrx1b's role in directing pro-regenerative fibroblasts during zebrafish heart regeneration, reducing fibrosis and promoting tissue repair.

This study identifies tbx5a as essential for cardiac looping in zebrafish, showing that heart tube twisting depends on intrinsic tissue patterning and is independent of cell addition.

The paper identifies asymmetric Hapln1a expression in zebrafish heart development, showing it drives ECM expansion and promotes asymmetric heart morphogenesis through interaction with laterality cues.

The paper quantifies cardiomyocyte regeneration in zebrafish after injury, finding complete numerical replacement but incomplete differentiation and scar resorption.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

The paper identifies actomyosin dynamics and Notch/Bmp signaling as drivers of apical extrusion of proepicardial cells in zebrafish during heart development.