Construction and Experimental Validation of a Petri net Model of Wnt/β-catenin Signaling
Annika Jacobsen, Nika Heijmans, Folkert Verkaar, Martine J. Smit, Jaap Heringa, Renée van Amerongen, K. Anton Feenstra
This study constructs and validates a Petri net model of Wnt/β-catenin signaling to investigate its behavior under physiological and pathophysiological conditions, revealing dose- and time-dependent responses and higher pathway activity in hyperactive signaling.
bioRxiv · Mar 21, 2016Bioinformatics