Author

Nika Heijmans

University of AmsterdamORCID 0000-0002-5639-9407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Renée van AmerongeniD· 4 shared Katrin E. WieseiD· 2 shared Yorick Bernardus Cornelis van de GriftiD· 2 shared Annika JacobseniD· 1 shared Antonius L. van BoxteliD· 1 shared Colin E.J. PritchardiD· 1 shared Folkert Verkaar· 1 shared Ingeborg B. HooijkaasiD· 1 shared

Activity by Year

2016-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersDevelopmental Biology

Renée van AmerongenORCID

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4 papers

Recent·Most cited

GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers

Yorick Bernardus Cornelis van de Grift, Marleen T. Aarts, Katrin E. Wiese, Nika Heijmans, Ingeborg B. Hooijkaas, Colin E.J. Pritchard, Linda Henneman, Paul Krimpenfort, Antonius L. van Boxtel, Renée van Amerongen

The paper identifies GRHL and PGR proteins as regulators of WNT4 expression in mammary glands through 3D chromatin looping mechanisms.

bioRxiv · Apr 11, 2025 · PreprintDevelopmental Biology

Transcriptomic analysis of pubertal and adult virgin mouse mammary epithelial and stromal cell populations

Nika Heijmans, Katrin E. Wiese, Jos Jonkers, Renée van Amerongen

The paper analyzes bulk RNAseq data from mouse mammary epithelial and stromal cells during puberty and adult virgin estrous cycles to study gene expression changes related to hormone fluctuations.

Journal of Mammary Gland Biology and Neoplasia · Jun 25, 2024Peer-reviewedDevelopmental Biology

How to use online tools to generate new hypotheses for mammary gland biology research: a case study for Wnt7b

Yorick Bernardus Cornelis van de Grift, Nika Heijmans, Renée van Amerongen

The paper demonstrates how online tools can be used to generate hypotheses about Wnt7b regulation in mammary gland biology through in silico analysis of -omics datasets.

Journal of Mammary Gland Biology and Neoplasia · Dec 1, 2020Peer-reviewedDevelopmental Biology

Construction and Experimental Validation of a Petri net Model of Wnt/β-catenin Signaling

Annika Jacobsen, Nika Heijmans, Folkert Verkaar, Martine J. Smit, Jaap Heringa, Renée van Amerongen, K. Anton Feenstra

This study constructs and validates a Petri net model of Wnt/β-catenin signaling to investigate its behavior under physiological and pathophysiological conditions, revealing dose- and time-dependent responses and higher pathway activity in hyperactive signaling.

PLOS ONE · May 24, 2016Peer-reviewedBioinformatics