Oligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress
Frances F. Diehl, Allen R. Buskirk, Rachel Green
In starved HEK293T cells, RIOK3 recruits TUT7 and DIS3L2 to 40S ribosomes; TUT7 adds 3′ oligo(U) tails to 18S rRNA and DIS3L2 degrades it 3′ to 5′.
Molecular Cell · Oct 1, 2026Peer-reviewedMolecular Biology✦ In-depth digest