Allen R. Buskirk

In starved HEK293T cells, RIOK3 recruits TUT7 and DIS3L2 to 40S ribosomes; TUT7 adds 3′ oligo(U) tails to 18S rRNA and DIS3L2 degrades it 3′ to 5′.

The paper shows that different drugs inducing ribosome collisions lead to distinct cellular responses through varied signaling pathways and structural changes in ribosomes.

The paper shows that HrpA, an RNA helicase in E. coli, rescues stalled ribosomes by splitting collided ribosomes into subunits using ATP hydrolysis.

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

Riboformer predicts context-dependent translation dynamics using deep learning, correcting artifacts and identifying sequence motifs affecting ribosome stalling.

This study shows that MutS2 in B. subtilis splits stalled ribosomes into subunits without cleaving mRNA, differing from the E. coli SmrB mechanism.

The paper identifies SmrB as a factor that cleaves mRNAs upstream of stalled ribosomes in bacteria, promoting ribosome rescue through ribosome collisions.

This study uses ribosome profiling in Haloferax volcanii to uncover leaderless translation, novel initiation sites, and ribosome pausing, revealing complex translation mechanisms in Archaea.