A new LD protein, ApoL6 disrupts the Perilipin 1-HSL interaction to inhibit lipolysis
Yuhui Wang, Hai P. Nguyen, Pengya Xue, Ying Xie, Danielle Yi, Frances Lin, Jose Abraham Viscarra, Nnejiuwa U. Ibe, Robin E. Duncan, Hei Sook Sul
This study identifies ApoL6 as a lipid droplet protein that inhibits lipolysis by disrupting the Perilipin 1-HSL interaction, leading to changes in adipose tissue mass and metabolic outcomes.
bioRxiv · Nov 10, 2022 · PreprintMolecular Biology