Dot1L interacts with Zc3h10 to activate UCP1 and other thermogenic genes
Danielle Yi, Hai P. Nguyen, Jennie Dinh, Jose Abraham Viscarra, Ying Xie, Frances Lin, Madeleine Zhu, Jon M. Dempersmier, Yuhui Wang, Hei Sook Sul
This study identifies Dot1L as a coactivator that interacts with Zc3h10 to activate thermogenic genes like UCP1, essential for brown fat function and energy expenditure.
eLife · Oct 27, 2020Peer-reviewedDevelopmental Biology