Hai P. Nguyen

This study uses single-cell sequencing to identify cellular and molecular differences in the kidneys and pancreases of insectivorous and frugivorous bats, linking them to diabetes-related mechanisms.

This study identifies ApoL6 as a lipid droplet protein that inhibits lipolysis by disrupting the Perilipin 1-HSL interaction, leading to changes in adipose tissue mass and metabolic outcomes.

The paper integrates single-cell RNA and ATAC-seq data from mouse and human hypothalamus to identify sex-specific genes and obesity-associated regulatory elements.

This study identifies ADGRG6 as a gene involved in adipogenesis and sex-specific fat distribution, showing its potential as a therapeutic target for metabolic disease.

This study identifies Dot1L as a coactivator that interacts with Zc3h10 to activate thermogenic genes like UCP1, essential for brown fat function and energy expenditure.