Single genome analysis of normal cells identifies the early steps of kidney cancer.
Jean Piero Margaria, Giovanni Battista Pipitone, Alessandro Larcher, Sipontina Faienza, Isaline Rowe, Francesca Corea, Valentina Piatti, Nicola Sala, Jose Manuel Garcia Manteiga, Jianfeng Ge, David Mas-Ponte, Gianfranco Distefano, Sakari Vanharanta, Umberto Capitanio A, Fran Supek, , Irene Franco
The paper identifies a mutational signature in normal kidney cells linked to kidney cancer initiation through hypoxia-driven genetic changes.
bioRxiv · Sep 7, 2026 · PreprintCancer Biology