Author
University of HelsinkiORCID 0000-0001-5619-7963Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan…·Abhishek A. Chakraborty
The paper identifies BCL-XL dependence as a common vulnerability in various kidney cancer subtypes and develops a model to predict it using biomarkers like AMPK activation.
Jean Piero Margaria, Giovanni Battista Pipitone, Alessandro Larcher…·Irene Franco
The paper identifies a mutational signature in normal kidney cells linked to kidney cancer initiation through hypoxia-driven genetic changes.
Jianfeng Ge, Shoko Hirosue, Leticia Castillon…·Sakari Vanharanta
This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.
Teijo S. Pellinen, Lassi Luomala, Kalle Mattila…·Tuomas K. Mirtti
The paper identifies FAP-expressing EMT-associated cancer cells in highly inflamed localized ccRCC as an aggressive, immunosuppressive subtype linked to poor prognosis and metastasis.
Tianyi Xiao, Caillan Crowe‐McAuliffe, Moritz Ochmann…·Jussi Taipale
This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.