Disrupting Pregnane X Receptor Signaling Overcomes Temozolomide Resistance in Glioblastoma via Succisa pratensis-Derived Metabolites
Francesca Servidio, Fabio Pirovano, Sofia Remedia, Chiara Pellizzer, Martina Nespoli, Bruno G. Galuzzi, Marcella Bonanomi, Sara Mallia, Mauro Commisso, Flavia Guzzo, Clarissa Gervasoni, Daniela Gaglio, Manuela Moriggi, Daniele Capitanio, Gloria Rita Bertoli, , Alessia Lo Dico
This paper shows that Succisa pratensis enhances temozolomide efficacy in glioblastoma by inducing metabolic vulnerability and impairing PXR signaling.
bioRxiv · Jun 26, 2026 · PreprintCancer Biology