Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced tau mislocalization and synaptotoxicity
Beatriz Gomez Perez‐Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vázquez-Villaseñor, María Jiménez-Sánchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo, Wendy J. Noble
This study shows that astrocytic CXCL1 contributes to Aβ-induced tau mislocalization and synaptotoxicity via CXCR2, suggesting it as a therapeutic target in Alzheimer's disease.
Journal of Neuroinflammation · Dec 1, 2021Peer-reviewedNeuroscience