Wendy J. Noble

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Properties of Alzheimers disease brain-derived tau aggregates define tau processing by human astrocytes.

This study shows that tau aggregates from Alzheimer's disease brains are taken up and processed by human astrocytes, with differences in handling linked to astrocyte responses and gene expression changes.

Tau-mediated synaptic dysfunction is coupled with HCN channelopathy

The paper shows that HCN channel dysfunction is linked to tauopathies, with altered synaptic structure and function in Alzheimer's and Tau35 mouse models.

Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric Abeta

This study uses proteomics to analyze astrocyte secretome changes in response to soluble Aβ oligomers, identifying dysregulated proteins and potential biomarkers for Alzheimer's disease.

Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced tau mislocalization and synaptotoxicity

This study shows that astrocytic CXCL1 contributes to Aβ-induced tau mislocalization and synaptotoxicity via CXCR2, suggesting it as a therapeutic target in Alzheimer's disease.

Tau accumulates in Crohn's disease gut

The paper examines tau expression and phosphorylation in Crohn's disease and ulcerative colitis, finding upregulated tau isoforms in Crohn's disease via reduced protein clearance.

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release

This study shows that BIN1 loss in Alzheimer's disease leads to tau mislocalization and altered synaptic structure and tau release.