Author
University of SheffieldORCID 0000-0003-0067-8500Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Monika A. Myszczynska, Matthew J. Stopford, Nóra M. Márkus…·Laura Ferraiuolo
This paper uses AI to identify gefitinib as a potential ALS treatment, showing it protects motor neurons and reduces TDP-43 fragments in vitro and in vivo.
Amy F. Keerie, Raquel Rua Martins, Chloe F. Allen…·Richard J. Mead
M102, a dual NRF2/HSF1 activator, slows disease progression in 2 mouse models and exerts neuroprotection in human cellular models of ALS.
Beatriz Gomez Perez‐Nievas, Louisa Johnson, Paula Beltran-Lobo…·Wendy J. Noble
This study shows that astrocytic CXCL1 contributes to Aβ-induced tau mislocalization and synaptotoxicity via CXCR2, suggesting it as a therapeutic target in Alzheimer's disease.
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza…·Guillaume M. Hautbergue
This study shows that inhibiting SRSF1-dependent nuclear export of C9ORF72-repeat transcripts in ALS models protects neurons and identifies key RNA changes involved in disease.
Aurélie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes…·Heather Mortiboys
The paper shows that PRKN mutations impair mitophagy in dopaminergic neurons during a metabolic switch to oxidative phosphorylation.