Characterization of the phototoxicity, chemigenetic profile, and mutational signatures of the chemotherapeutic CX-5461 in Caenorhabditis elegans
Frank B. Ye, Akil Hamza, Tejomayee Singh, Stéphane Flibotte, Philip Hieter, Nigel J. O’Neil
This study characterizes the phototoxicity, chemigenetic profile, and mutational signatures of CX-5461 in C. elegans, showing it induces diverse mutations and requires multiple repair pathways.
Genetics · May 15, 2020Peer-reviewedGenetics