Nigel J. O’Neil

This study shows that human cohesin cannot function in yeast and disrupts endogenous cohesin biology when expressed heterologously.

The paper discovers that haploid chromosomes in two pathogenic fungi are segregated into separate nuclei, challenging the traditional view of nuclear chromosome content.

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

This study characterizes the phototoxicity, chemigenetic profile, and mutational signatures of CX-5461 in C. elegans, showing it induces diverse mutations and requires multiple repair pathways.

The paper assembles a complex C. elegans genome using MinION long-read sequencing and identifies genomic rearrangements not detectable with Illumina data.