Stéphane Flibotte

The paper develops a FRET-based system to analyze 2A peptides' activity, identifies key residues, and discovers a novel subclass with high StopGo efficiency.

The paper investigates the functional divergence of TBP homologs across species by analyzing their ability to complement TBP inactivation in yeast and identifies the role of the N-terminal domain in species-specific activity.

The paper shows that ribosome biogenesis affects translational regulation of non-optimal codon transcripts during IFN stimulation.

The paper identifies a regulatory network involving SEX-1 and PAL-1 in C. elegans ventral nerve cord development, showing their roles in motor neuron positioning.

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

This study shows that IPPK-1 and IP6 are critical for ventral nerve cord assembly in C. elegans, with IP6 rescue of mutant defects.

This study shows that ZDHHC9 loss in mice disrupts oligodendrocyte subtypes and myelination, linking it to white matter deficits in XLID.

This study identifies differentially palmitoylated proteins in the mouse hippocampus after fear conditioning and shows that palmitoylation of PRG-1/LPPR4 is essential for synapse plasticity.

The paper curates RNA-seq data of palmitoylating and de-palmitoylating enzymes in the mouse brain and identifies region and cell-type specific expression patterns.

This study identifies 58 essential genes in C. elegans using whole genome sequencing of maternal-effect lethal and sterile mutants, revealing novel alleles and functional roles in embryonic development and fertilization.

This study characterizes the phototoxicity, chemigenetic profile, and mutational signatures of CX-5461 in C. elegans, showing it induces diverse mutations and requires multiple repair pathways.

This study identifies TRAP as essential for insulin biogenesis, showing it facilitates preproinsulin translocation and affects downstream processing and secretion.

This paper identifies a meiosis-specific function of the phosphatase GSP-2 in promoting germ cell immortality through small RNA-mediated genome silencing in C. elegans.

The paper develops an optimized CRISPR/Cas9 protocol for generating deletions in C. elegans, demonstrating high efficiency and minimal off-target effects.