Two engineered AAV capsid variants for efficient transduction of human cortical neurons directly converted from iPSC
Sandra Elisabeth Fischer, Benjamin Strobel, Jonas Weinmann, Frank Gillardon
The paper evaluates two engineered AAV capsid variants for transducing human cortical neurons derived from iPSCs, finding that AAV2-NNPTPSR efficiently transduces both glutamatergic and GABAergic neurons, while AAV9-NVVRSSS also transduces astrocytes.
Journal of Neuroscience Methods · Dec 22, 2021Peer-reviewedNeuroscience