Benjamin Strobel

This study introduces STARR-CRAAVT, a platform to identify cell type-specific enhancers for gene therapy, showing promoter preference and enhancer positioning significantly affect activity.

This study investigates ligand-specific AXL signaling in IPF, showing GAS6 promotes basal cell proliferation while PROS1 inhibits it, with implications for therapeutic targets.

The paper identifies O-GlcNAcylation of JUNB as a regulator of promoter accessibility in metabolic genes, driving aberrant epithelial lineage in IPF.

In Silico Treatment evaluates animal models for disease relevance by simulating gene expression changes in humans, identifying suitable models and drug effects.

The paper evaluates two engineered AAV capsid variants for transducing human cortical neurons derived from iPSCs, finding that AAV2-NNPTPSR efficiently transduces both glutamatergic and GABAergic neurons, while AAV9-NVVRSSS also transduces astrocytes.