Integrated forward and reverse degradomics uncovers the proteolytic landscape of aortic aneurysms and the roles of MMP9 and mast cell chymase
Sumit Bhutada, Daniel R. Martin, Frank S. Cikach, Emidio Germano da Silva, Belinda B. Willard, Bhama Ramkhelawon, Mina K. Chung, Shataakshi Dahal, Anand Ramamurthi, Jayadev Joshi, Daniel J Blankenberg, John Barnard, Eugene H. Blackstone, Eric E. Roselli, Suneel Apte
The paper uses forward and reverse degradomics to analyze proteolytic landscapes in aortic aneurysms, identifying key proteases like MMP9 and CMA1 and their roles in extracellular matrix remodeling.
Arteriosclerosis Thrombosis and Vascular Biology · Apr 2, 2026Peer-reviewedBiochemistry