Suneel Apte

The paper combines SRPC-microCT with spatial transcriptomics and histology to enable 3D cardiac phenotyping in mice, linking structural and molecular data.

The paper uses forward and reverse degradomics to analyze proteolytic landscapes in aortic aneurysms, identifying key proteases like MMP9 and CMA1 and their roles in extracellular matrix remodeling.

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

This study identifies the versican-hyaluronan complex as essential for vasculogenesis and primitive hematopoiesis by providing a niche for Flk1+ progenitors during gastrulation.

The paper identifies differential proteoglycan dynamics in umbilical artery and vein as the mechanism ensuring rapid arterial closure and venous patency at birth.

This study shows that ADAMTSL2 deletion in limb soft tissues, particularly tendons, causes disproportionate limb shortening by affecting tendon growth and fibrillin microfibril formation, suggesting a new mechanism for geleophysic dysplasia.