A Regulatory Axis for Tonotopic MYO7A Expression in Cochlear Hair Cells
Sihan Li, Sujin Jun, Ye‐Ri Kim, Ayathi Gogineni, Franklin Lee, C. K. Kim, Un-Kyung Kim, Anthony W. Peng, Jung‐Bum Shin
The paper identifies a cis-regulatory element, EnhancerA, and the transcription factor SIX2 that regulate tonotopic Myo7a isoform expression in cochlear hair cells, linking cochlear position to protein diversity and function.
Proceedings of the National Academy of Sciences · Apr 7, 2026Peer-reviewedNeuroscience