Sihan Li

This study identifies ATP8B1 and TMEM30B as essential for maintaining lipid asymmetry in outer hair cells, crucial for hearing and preventing hair-cell degeneration.

The paper identifies a novel MYO7A isoform, MYO7A-N, and shows its distinct expression and function in outer hair cells, contributing to hearing sensitivity and cochlear frequency resolution.

The paper identifies a cis-regulatory element, EnhancerA, and the transcription factor SIX2 that regulate tonotopic Myo7a isoform expression in cochlear hair cells, linking cochlear position to protein diversity and function.

The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.

This study shows that PIP2-Tmie interactions, not myosin motors, drive slow adaptation in mammalian hair cells, as demonstrated by rescue experiments and disruption studies.

This study uses single-cell RNA sequencing to analyze sputum cells from asthma patients and controls, identifying dysregulated pathways and communication networks involved in asthma pathogenesis.

The paper shows that XIRP2 facilitates repair of noise-induced damage to stereocilia F-actin cores in mouse auditory hair cells by enriching monomeric gamma-actin at damaged sites.

This study shows that apoptosis and necroptosis contribute to cisplatin and aminoglycoside ototoxicity, with potential for therapeutic intervention.