Jung‐Bum Shin

This study identifies ATP8B1 and TMEM30B as essential for maintaining lipid asymmetry in outer hair cells, crucial for hearing and preventing hair-cell degeneration.

The paper identifies a novel MYO7A isoform, MYO7A-N, and shows its distinct expression and function in outer hair cells, contributing to hearing sensitivity and cochlear frequency resolution.

The paper identifies a cis-regulatory element, EnhancerA, and the transcription factor SIX2 that regulate tonotopic Myo7a isoform expression in cochlear hair cells, linking cochlear position to protein diversity and function.

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

This study shows that PIP2-Tmie interactions, not myosin motors, drive slow adaptation in mammalian hair cells, as demonstrated by rescue experiments and disruption studies.

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

The paper shows that XIRP2 facilitates repair of noise-induced damage to stereocilia F-actin cores in mouse auditory hair cells by enriching monomeric gamma-actin at damaged sites.

This study identifies LMO7 as a hair cell protein localized to the cuticular plate, showing that its deficiency leads to structural defects and progressive hearing loss.

This study shows that apoptosis and necroptosis contribute to cisplatin and aminoglycoside ototoxicity, with potential for therapeutic intervention.