Primary CD34+ cells of patients with VEXAS syndrome are highly sensitive to targeted treatment with TAK-243 and pevonedistat
Daniel Nowak, Marie Demmerle, Alessa Klär, Alexander Streuer, Vladimir Riabov, Eva Altrock, Felicitas Rapp, Ann‐Christin Belzer, Teresa Klink, Meret Hahn, Franziska Hofmann, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, , Nanni Schmitt
This study shows that VEXAS patient-derived CD34+ cells are more sensitive to TAK-243 and pevonedistat than MDS and healthy controls, suggesting potential targeted therapy.
bioRxiv · May 22, 2025 · PreprintCancer Biology