Author
Heidelberg UniversityORCID 0000-0001-7130-7921Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Daniel Nowak, Marie Demmerle, Alessa Klär…·Nanni Schmitt
This study shows that VEXAS patient-derived CD34+ cells are more sensitive to TAK-243 and pevonedistat than MDS and healthy controls, suggesting potential targeted therapy.
Karen Grimes, Hyobin Jeong, Amanda Amoah…·Jan O. Korbel
This study identifies cell type-specific molecular consequences of mosaic structural variants in hematopoietic stem and progenitor cells across aging.
Hyobin Jeong, Karen Grimes, Peter‐Martin Bruch…·Jan O. Korbel
This paper introduces scNOVA, a method to analyze somatic structural variants in single-cell multiomics data, revealing their functional impacts on gene regulation and cancer pathways.
Wei‐Yu Lin, Sarah Elizabeth Fordham, Eric A. Hungate…·James M. Allan
This study identifies two genome-wide significant susceptibility loci for acute myeloid leukemia through a meta-analysis of GWAS data.
Lars Velten, Benjamin A. Story, Pablo Hernández-Malmierca…·Lars Michael Steinmetz
The paper identifies and profiles leukemic and pre-leukemic stem cells using single-cell transcriptomics combined with lineage tracing via somatic variants.