A Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage
Liam Thomas Hales, Paul M. Tammiste, Adam J. Walker, Rebecca Bryce, Andrew Sugden, Axel Knebel, Rachel L. Toth, Fred Lamoliatte, Marian Péteri, Oliwia Curry, Virginia De Cesare, Chiara Maniaci
This study identifies USP5 as the protease responsible for cleaving SDE2UBL, revealing a novel regulatory mechanism for SDE2 function through UBL-directed cleavage.
bioRxiv · May 23, 2025 · PreprintBiochemistry