Rachel L. Toth

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

The paper identifies SRPK-mediated phosphorylation of MAP1S, showing it regulates proteolytic processing and microtubule binding during neurodevelopment.

The paper tests eCF506, a c-Src inhibitor, showing it reduces opioid tolerance by decreasing β-arrestin2 recruitment without affecting cAMP inhibition.

This study identifies USP5 as the protease responsible for cleaving SDE2UBL, revealing a novel regulatory mechanism for SDE2 function through UBL-directed cleavage.

The paper develops a chemical-genetic system to inhibit PP2A-B56 phosphatase by blocking SLiM-binding pockets, revealing its role in kinetochore-microtubule attachments.

This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

This paper identifies a novel RLIM variant causing severe Tonne-Kalscheuer syndrome by disrupting protein stability and function.

The paper identifies a RNF12-USP26 amplification loop critical for germ cell specification and shows its disruption in urogenital disorders.

The paper shows SRPK regulates ubiquitin-dependent neurodevelopmental signalling by phosphorylating RNF12, linking SRPK mutations to intellectual disability.