Twitchin kinase, a mechanoreceptor in the muscle sarcomere, is a catalytically-primed moonlighting kinase
Peter Gravenhorst, Frederic Berner, Hiroshi Qadota, Till Dorendorf, Tiankun Zhou, Rhys M. Williams, Michael Kovermann, Guy M. Benian, Olga M. Mayans
This study investigates the substrate targeting and functional role of twitchin kinase (TwcK) in C. elegans muscle, revealing its moonlighting role and distinct activation mechanism.
bioRxiv · May 20, 2026 · PreprintBiophysics