Increased 5-HT2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics
Aurelija Ippolito, Sridhar R. Vasudevan, Shaun Hurley, Gary Gilmour, Frederick G. Westhorpe, Grant C. Churchill, Trevor Sharp
This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.
British Journal of Pharmacology · Jun 22, 2025Peer-reviewedPharmacology & Toxicology