Gary Gilmour

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This study examines the acute and post-acute effects of psilocybin and LSD on cognitive flexibility in rats using two probabilistic reversal learning tasks, finding no robust enhancement of reversal learning.

This study shows psilocybin reduces neuropathic pain in mice and enhances gabapentin's effectiveness through 5-HT2A receptor mechanisms.

This study investigates how different serotonergic psychedelics and MDMA affect affective biases in male rats, finding varied impacts on memory and new experiences that may relate to their antidepressant potential.

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Psilocybin reverses reward learning deficits in a rat model of depression within 24 hours, with effects lasting at least 7 days.

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

This study shows that GluA1 dysfunction leads to impaired short-term habituation, resulting in a hyper-dopaminergic phenotype in the nucleus accumbens, which may contribute to aberrant salience in schizophrenia.

This study investigates how xanomeline, an M1/M4 agonist, affects brain functional connectivity in mice using phMRI, rsfMRI, and qEEG, showing both direct and modulatory effects on neural activity and connectivity.

This study shows amphetamine disrupts prediction error signals in nucleus accumbens and orbitofrontal cortex in rats during learning tasks.