Trevor Sharp

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This paper introduces ultrasound-mediated neuromodulator delivery to study serotonergic control of context-dependent motivation in primates, showing altered neural activity and reduced reward environment influence.

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

This study shows that perinatal serotonin signalling affects cortical GABAergic circuit development, leading to lifelong sensory encoding changes.

This study shows that stopping SSRIs like paroxetine leads to increased 5-HT activity in the brain, causing anxiety-like behaviors and changes in neurotransmitter levels.

This study investigates the role of 5-HT-glutamate co-releasing neurons in stress response using genetic and behavioral experiments in mice.

This paper computationally models neuromodulator circuits to show that multiple stable architectures can produce similar network activity, demonstrating degeneracy in dopamine and serotonin systems.

This study shows that 5-MeO-DMT induces a dissociated brain state in mice with features of both wakefulness and sleep, including slow waves and pupil dilation, while suppressing REM sleep.

This study investigates the effect of SSRI discontinuation on anxiety-like behaviors in mice, finding short-lasting behavioral changes in males but not females.

This study shows psilocin disrupts sleep patterns and affects local but not global sleep homeostasis in mice, potentially linking to its antidepressant effects.

This study shows that reducing serotonin transporter activity in mice enhances aversive learning and amygdala responsivity, supporting a network plasticity theory of serotonin function.