Grant C. Churchill

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This paper demonstrates that levacetylleucine modulates TFEB activity in a bidirectional manner, normalizing lysosomal function in both wild-type and NPC1 knockout cells.

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

This paper shows that NALL activates TFEB, enhancing lysosomal and autophagic function, which may explain its therapeutic effects in neurodegenerative diseases.