Phase separation drives SNARE complexes formation
Feng Chen, Qiongwei Ke, Sifan Feng, Huiyi Chen, Qin Haung, Fubin Ma, Yujie Cai, Ji Chen, Shengnan Li, Wenyan Wei, Yuanhong Sun, Xiao Jun Peng, Tong Lin, Xiaocong Sun, Liehua Deng, , Lili Cui
This study shows that phase separation drives SNARE complex formation and aggregation, with syntaxin1 non-IDRs necessary for this process, and identifies its role in recruiting synaptic vesicles.
bioRxiv · Mar 4, 2025 · PreprintNeuroscience